Chemical Speciation of Metal Ions and its Biological Relevance
Tamás Kiss
Department of Inorganic and Analytical Chemistry, University of Szeged, Hungary
Corresponding author: Prof. Tamás Kiss
Department of Inorganic and Analytical Chemistry
University of Szeged
P.O.B. 440
H-6701 Szeged, Hungary
Telephone: +36 62 544-337
Fax number: +36 62 420-505
E-mail address: tkiss@chem.u-szeged.hu
CEJOEM 2002, Vol.8. No.2–3.:104–117
Key words:
Biospeciation, Al(III), VO(IV), insulinomimetics, blood serum, Ca(II)
Abstract:
The paper gives a brief insight into chemical speciation: the definition, the methods available
to study the solution state of metal ions, and the relevance of speciation in biology. In order to
describe the solution state of these metal ions in the organism, speciation of the toxic Al(III),
the beneficial VO(IV) and Ca(II) in various biofluids and tissues is treated. The importance of
ternary complex formation with endogenous biomolecules is emphasised. The relevance of the
biospeciation of Al(III) ion in its transport and involvement in neurological disorders, and that
of insulinomimetic VO(IV) complexes and Ca(II) in mineralisation/demineralisation processes is discussed.
Received: 3 July 2002
Accepted: 31 October 2002
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