Acute Oral Toxicity and Dermal Irritation Test of Indium Chloride
Éva Szakmáry1, Mária Mándy1, Márta
Kovács2, Erzsébet Tátrai1, and György Ungváry2
1 National Institute of Occupational Health, József Fodor National Center for Public Health, Budapest, Hungary
2 József Fodor National Center for Public Health, Budapest, Hungary
Corresponding author: Prof. György Ungváry MD., PhD., DSc.
Fodor József National Center for Public Health
P.O. Box 22.
H-1450, Budapest, Hungary
Telephone: (+36) 1-215-5491
Fax number: (+36)1-215-6891
E-mail: ungvary@fjokk.hu
CEJOEM 2001, Vol.7. No.1.:60-65
Key words:
Indium chloride, acute oral toxicity, acute dermal irritation
Abstract:
Acute oral and dermal toxicity effects of indium chloride were studied on SPRD rats and New Zealand rabbits. The tests were performed according to OECD Guidelines for Test8ing of Chemicals. In acute oral toxicity study of indium chloride, the LD50 values amounted to 1983 mg/kg both in male and female rats. The confidence interval values were LD84–2283 mg/kg and LD16–1741 mg/kg, respectively. The dose level of 500 mg of indium chloride caused severe irreversible dermal damages, i.e., it proved to be irritative and corrosive. On the basis of our earlier and present studies, the toxicity and hazardousness of indium chloride can be classified as follows: Harmful. Danger symbol: Xn harmful, C corrosive. R numbers/phrases: 22-34-61, S numbers/phrases: 24/25-26-27/28-46.
Received: 27 February 2001
Accepted: 03 March 2001
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