“Critical Period” of the Teratogenic Effect of Indium

Éva Szakmáry1 and György Ungváry2

1 National Institute of Occupational Health, József Fodor National Center for Public Health, Budapest, Hungary
2 József Fodor National Center for Public Health, Budapest, Hungary

Corresponding author: Éva Szakmáry Ph. D.
    National Institute of Occupational Health
    József Fodor National Center for Public Health
    H-1450 Budapest
    P.O. Box 51, Hungary
    Telephone: (+36) 1 476 1100
    Fax number: (+36) 1 216 9907
    E-mail: ncph@elender.hu

CEJOEM 2000, Vol.6. No.1.:33-37


Key words:
Skeletal major abnormalities, visceral major abnormalities, and external malformation


Abstract:
The critical period within the organogenesis of the teratogenic effect of indium (so-called teratogenic determinative period) was investigated. Groups of pregnant SPRD rats were treated with 0 or 400 mg/kg b. w. indium chloride intragastrically on one of the days 8-15 of gestation. On the 21st gestational day dams and fetuses were evaluated by the usual methods of experimental teratology. It was found that the effect of indium causing fetal retardation (of body weight, visceral and skeletal) was independent of the exposure time. Teratogenic effect occurred with treatment on days 10, 11, 12, 14, or 15 of gestation. The teratogenic effect was the strongest on days 11 and 12 of gestation when indium caused gross external malformations. On days 10, 11, and 14 of gestation, indium caused some skeletal abnormalities, and on days 14 and 15 of gestation the urogenital system was affected.


Received:  14 February 2000
Accepted:  29 February 2000

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