“Critical Period” of the Teratogenic Effect of Indium
Éva Szakmáry1 and György Ungváry2
1 National Institute of Occupational Health, József Fodor National
Center for Public Health, Budapest, Hungary
2 József Fodor National Center for Public Health, Budapest, Hungary
Corresponding author: Éva Szakmáry Ph. D.
National Institute of Occupational Health
József Fodor National Center for Public Health
H-1450 Budapest
P.O. Box 51, Hungary
Telephone: (+36) 1 476 1100
Fax number: (+36) 1 216 9907
E-mail:
ncph@elender.hu
CEJOEM 2000, Vol.6. No.1.:33-37
Key words:
Skeletal major abnormalities, visceral major abnormalities, and external malformation
Abstract:
The critical period within the organogenesis of the teratogenic effect of indium
(so-called teratogenic determinative period) was investigated. Groups of pregnant SPRD
rats were treated with 0 or 400 mg/kg b. w. indium chloride intragastrically on one
of the days 8-15 of gestation. On the 21st gestational day dams and fetuses were
evaluated by the usual methods of experimental teratology. It was found that the effect
of indium causing fetal retardation (of body weight, visceral and skeletal) was
independent of the exposure time. Teratogenic effect occurred with treatment on days
10, 11, 12, 14, or 15 of gestation. The teratogenic effect was the strongest on days
11 and 12 of gestation when indium caused gross external malformations. On days 10,
11, and 14 of gestation, indium caused some skeletal abnormalities, and on days 14
and 15 of gestation the urogenital system was affected.
Received: 14 February 2000
Accepted: 29 February 2000
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