Correlation of Plasma Ca, Mg, Cu, Zn Levels in Diabetic Rats Treated
with Hipogalegin
Emilia Creteanu1, H. Creteanu2, Carmen Ionut3,
J. Madar4, M. Tamas3
1 Institute of Public Health, Cluj, Romania
2 City Hospital Campia-Turzii, Romania
3 University of Medicine and Pharmacy Cluj, Romania
4 Institute of Biological Research, Cluj, Romania
Corresponding author: Emilia Creteanu
Institute of Public Health, Cluj, Romania
Mailing adress: Institute of Public Health, Pasteur St. 6, Cluj-Napoca,
3400, Romania
Telephone: 00-40-64-194 2252
Fax: 00-40-64-199 891
E-mail: root@jeffmcm.soroscj.ro
CEJOEM 1998, Vol.4. No.2.:140-145
Key words:
Plasma-calcium, -magnesium, -cooper, -zinc, magnesium in erythrocytes,
experimental diabetes
Abbreviations:
H = hipogalegin
ins. = insulin
STZ = streptozotocin
Abstract:
Within the last years, biological role and properties of metal ions have
begun to be reconsidered due to greater importance of inorganic bioions
in explanation of numerous biologic processes. The aim of the present survey
is to establish and to evaluate a real correlation between the Zn, Cu,
Ca plasma Mg and erythrocyte Mg levels, in 56-day old Wistar male rats
with diabetes induced by iv administration of a single dose 6.5 mg 100
g b.w. STZ (streptozotocin), after 18 hour starvation. In order to control
the experimentally elevated blood sugar levels, in one group we used for
30 days 0.1 ml novolent insulin administration every day and in another
rat group we tested the blood sugar level diminishing effect of vegetal
extract “Hipogalegin” (H) (0.45 g/kg b.w./day). The effect of H in the
STZ diabetic rats is responsible for bringing the blood sugar levels within
the normal range back, and for statistically decreasing the blood sugar
levels in comparison with the STZ induced diabetic group (p<0.001).
The lower plasma levels of Ca, Mg, Cu and Zn and the increased levels of
erythrocyte Mg strongly recognised in the diabetic and untreated animals,
underline the close relationship between these electrolytes. The survey
suggests that erythrocyte Mg level and the plasma Zn level have an opposite
behaviour in STZ animals (r = –0.58625). The experimental potential of
the Hipogalegin-vegetal extract is significant towards controlling the
blood sugar level and maintaining a good ionic balance in diabetic rats.
Received: 08 July 1997
Accepted: 16 April 1998
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Posted: 15 November 1998