Plasma Lipid Peroxide Level in Workers Exposed to Lead
Violeta B. Tenchova1, Vera P. Petkova2, Sonya
D. Pavlova2, Yuri P. Simeonov2
1 National Centre of Radiobiology and Radiation Protection,
Sofia, Bulgaria
2 Clinic Centre of Occupational Diseases, Medical University,
Sofia, Bulgaria
Corresponding author: Violeta Tenchova, Ph.D.
National Centre of Radiobiology and Radiation Protection
132, Kl. Ohridsky Blvd.
1756 Sofia, Bulgaria
Fax: (+359) 2-621-059
Tel.: (+359) 2-626-037
CEJOEM 1998, Vol.4. No.1.:45-50
Key words:
Occupational exposure, lipid peroxidation, malondialdehyde, blood lead
concentration
Abbreviations:
AAS – Atomic absorbtion spectrometer
GSH – Glutathione
LPO – Lipid peroxidation
MDA – Malondialdehyde
PbB – Blood lead concentration
SOD – Superoxide dismutase
TBA – Thiobarbituric acid
TVL – Treshold value limit
Abstract:
The investigation involved 94 male workers occupationally exposed to
lead (PbB – 2.00 ± 0.74 mmol/l). 18 male subjects from the administrative
staff of the same plant (PbB – 1.30 ± 0.35 mmol/l) and 42 males
from non-contamined area (PbB – 0.86 ± 0.18 mmol/l). The plasma
malondialdehyde concentration (4.56 ± 0.65 nmol/ ml) was significantly
higher in workers exposed to lead than in donors from administrative staff
(3.90 ± 0.22 nmol/ml) and non-contaminated area (3.62 ± 0.46nmol/ml).
A positive correlation (r = 0.596) between MDA level and blood lead concentration
in workers occupationally exposed to lead was observed.
Received: 12 November 1997
Accepted: 2 February 1998
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Posted: 15 November 1998