Chromosomal Aberrations, Hormone Levels and Oxidative Phenotype (P450
2D6) in Low Occupational Lead Exposure
Daniela Pelclová1, Jana Pícková1,
and Vìra Patzelová2
1 Department of Occupational Diseases, First Faculty of Medicine,
Charles University, Prague
2 Centre of Industrial Hygiene and Occupational Diseases
of the State Institute of Public Health, Prague
Corresponding author: Dr Daniela Pelclová
Department of Occupational Diseases,
Vyšehradská 49,
128 21 CZ-Prague,
Czech Republic
Tel/Fax +4202/293868,
e- mail: pelclova@mbox.cesnet.cz
CEJOEM 1997, Vol.3. No.4.:314-322
Key words:
Lead, chromosomal analysis, testosterone, luteinizing hormone, follicle
stimulating hormone, P450 2D6, coproporphyrins, 5-aminolevulinic acid.
Abbreviations:
AB.C. = aberrant cells
5-ALA = 5-aminolevulinic acid
ATSDR = Agency for Toxic Substances and Disease Registry
CP = coproporphyrins
FSH = follicle stimulating hormone
IARC = International Agency for Research on Cancer
LH = luteinizing hormone
EM = extensive metabolizer (of sparteine)
PM = poor metabolizer (of sparteine)
SD = standard deviation
Abstract:
Chromosomal analysis was carried out in peripheral lymphocytes in a
group of 22 workers of a lead-battery plant with average blood lead concentration
of 24.6 µg/100 ml, and in the control group of 21 controls with average
blood lead concentration of 5.1 µg/100 ml. There was no statistical
difference in the percentage of chromosomal aberrations between them. The
blood levels of testosterone, luteinizing hormone (LH) and follicle stimulating
hormone (FSH) in the exposed group were in the normal range. Among the
group of 22 lead exposed workers two poor metabolizers (PM) of sparteine
were found, one PM was identified among the controls. The possible influence
of lead exposure and elevated 5-aminolevulinic acid (5-ALA) in vitro and
in vivo on the activity of P450 is discussed.
Received: 1 October 1997
Accepted: 12 December 1997
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Posted: 16 November 1998