The Low Dose Dilemma
Gy. J. Köteles
“Frédéric Joliot-Curie” National Research Institute for Radiobiology
and Radiohygiene, Budapest, Hungary
CEJOEM 1997, Vol.3. No.4.:342
The assessment of health hazards of low dose and low dose rate radiations
is usually performed by epidemiological surveys of the involved population.
It is getting more and more obvious, however, that the linear extrapolation
from data obtained at high dose range might be misleading. Accordingly,
the scientific community is attaching again great importance to the experimental
approaches to get more precise information on the risk and development
of stochastic radiation effects.
Data are presented and discussed on:
– the hit frequencies at cellular level,
– cellular mechanisms provoked by low doses,
– radiation-induced membrane alterations,
– radiation-induced increases of micronucleus frequencies in human
lymphocytes following external and internal irradiations.
Using the cytokinesis-blocked culturing of human lymphocytes,
data could be obtained for different reactions at low and at high doses.
The frequency curves of the individual increments of micronuclei following
in vitro X-irradiations demonstrated considerable differences in type and
shape of the probability distribution.
| Vol.3. No.4. | Back
| Full Text Review
|