Follow-up Four End-point Genotoxicological Monitoring among Adriamycin
Producing Workers
M. G. Jakab, J. Major, and A. Tompa
National Institute of Occupational Health, Budapest
CEJOEM 1997, Vol.3. No.4.:340
Authors present the results of four end-point follow-up genotoxicological
monitoring of 52 workers producing Adriamycin in order to detect the genotoxic
effects in the workers occupationally exposed to Adriamycin. The investigations
were annually repeated until the 6th year when Adriamycin production was
terminated. The results of these investigations were compared to the data
of 101 historical and 88 industrial controls. During the 5-year study the
variation frequency (VF) of HPRT point-mutations, chromosome aberrations
(CA) and sister chromatid exchanges (SCE) were determined together with
the measurement of UV-induced unscheduled DNA repair-synthesis (UDS) in
human peripheral blood lymphocytes. In the first 3 years of the study there
were no significant differences in the mean values of the results in all
subgroups of the workers (fermentors, producers and workers in the analytical
laboratories) in comparison to those of the industrial controls. However,
in all subgroups the results of both CA and VF were elevated in the 4th
year of the investigations. Parallel to these, a slight increase of SCE
and an increase in UDS (among fermentors) was also observed. In the final,
5th year of the study a decrease in CA and VF was detected in analytical
laboratory workers, while VF, CA and SCE values showed a further increase
in fermentors and producers. These results indicate an increase of genotoxic
damages suggested to be the consequence of exposure to Adriamycin and an
increased (tumor) risk among Adriamycin producing workers. The data also
confirm that a longer expression period after the exposure is needed for
the occurrence of detectable genotoxic damages.
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