Attenuation of Some Adverse Health Effects of Chrysotile Asbestos with a Bioprotective Complex in Animal Experiments

Larissa I. Privalova1, Boris A. Katsnelson1, Marina P. Sutunkova1, Irina E. Valamina2, Olga Yu. Beresneva2, Tamara D. Degtyareva1, and Olga S. Yeremenko1

1 Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
2 The Central Research Laboratory of the Urals State Medical Academy

Corresponding author: Professor Boris A. Katsnelson, MD, DSc
    Head, Dept. of Toxicology and Biological Prophylaxis,
    Medical Research Center for Prophylaxis & Health Protection
    30 Popov Str., Ekaterinburg 620014, Russia
    Telephone: 7-343-3718-721
    Fax number: 7-343-3718-740
    E-mails: BKaznelson@ymrc.ru; BKaznelson@etel.ru

CEJOEM 2007, Vol.13. No.3-4.: 265-276

Key words:
chrysotile asbestos, cytotoxicity, fibrogenicity, micronuclear assay, bioprotectors

Abbreviations:
AM
BALF
BPC
NL
SDH		 = alveolar macrophage
= bronchoalveolar lavage fluid
= bioprophylactic complex
= neutrophile leukocyte
= succinate dehydrogenase

Abstract:
It is shown in experiments on inbred rats and linear mice that a bioprotective complex composed of glutamate, methionine and a multivitamin and multimineral preparation of the VITRUM group reduces significantly: (a) changes in the cellular composition of the bronchoalveolar lavage fluid from rats that are associated with the cytotoxicity of chrysotile asbestos administered intratracheally; (b) the retention of asbestos dust in the pulmonary tissue, the development of the histological features of asbestosis and related changes in the mass of the lungs and their hydroxyproline and lipid contents within the framework of a long-term experiment; (c) some integral indices of the impact of asbestos on the organism; (d) the formation of micronuclei in bone marrow cells in mice administered asbestos intraperitoneally.

Received: 18 January 2008
Accepted: 5 March 2008
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