Antimicrobial Activity of Copper(II) Complexes with some Benzimidazole Derivatives against Microorganisms Widely Distributed in the Environment

Sanja O. Podunavac-Kuzmanović and Siniša L. Markov

Faculty of Technology, University of Novi Sad, Novi Sad, Serbia

Corresponding author: Sanja Podunavac-Kuzmanović, Ph.D.
    Faculty of Technology
    University of Novi Sad
    Bulevar Cara Lazara 1
    21000 Novi Sad, Serbia
    Telephone: +381 21 6350 122/589
    Fax number: +381 21 450 413
    E-mail: sanya@uns.ns.ac.yu

CEJOEM 2006, Vol.12. No.1.: 61–66


Key words:
Copper(II), benzimidazoles, complexes, antimicrobial activity


Abstract:
The paper presents antimicrobial investigations of copper(II) complexes with two series of benzimidazoles. The first one was based on 2-methylbenzimidazole, the second one contained 2-aminobenzimidazole. Antimicrobial activities of the ligands and their complexes were evaluated against three Gram-positive bacterial strains (Bacillus sp., Staphylococcus aureus and Sarcina lutea) one Gram-negative isolate (Pseudomonas aeruginosa), and yeast (Candida pseudotropicalis). The majority of the investigated compounds displayed in vitro antimicrobial activity against very persistent microorganisms. None of the compounds was significantly effective against yeast Candida pseudotropicalis. Minimum inhibitory concentration (MIC) was determined for all ligands and their complexes. The effect of ligand and complex structure on the antimicrobial activity is discussed.


Received: 5 December 2005
Accepted: 31 July 2006

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