Biological Activity of Zinc(II) and Nickel(II) Complexes with some 2-aminobenzimidazole Derivatives in Microorganisms of Environmental Relevance

Sanja O. Podunavac-Kuzmanović and Dragoljub M. Cvetković

Faculty of Technology, University of Novi Sad, Novi Sad, Serbia

Corresponding author: Sanja Podunavac-Kuzmanović, Ph.D.
    Faculty of Technology
    University of Novi Sad
    Bulevar Cara Lazara 1
    21000 Novi Sad, Serbia
    Telephone: +381 21 6350 122/589
    Fax number: +381 21 450 413
    E-mail: sanya@uns.ns.ac.yu

CEJOEM 2006, Vol.12. No.1.: 55–60

Key words:
Zinc(II), nickel(II), benzimidazoles, complexes, biological activity

Abstract:
Zinc(II) and nickel(II) chloride reacts with 2-aminobenzimidazole, 1-benzyl-2-aminobenzimidazole, and 1-(4-methylbenzyl)-2-aminobenzimidazole to form complexes. All the ligands and complexes were evaluated for their in vitro antimicrobial activity against Pseudomonas aeruginosa, Bacillus sp., Staphylococcus aureus, Sarcina lutea, and Saccharomyces cerevisiae. Minimum inhibitory concentrations were determined for all ligands and their complexes. It was found that the tested compounds were more active against Gram-positive than Gram-negative bacteria. None of the compounds were significantly effective against yeast Saccharomyces cerevisiae. Of the tested compounds, the complexes were same or more active than their starting ligands against the bacteria. The effect of ligand and complex structures on the antimicrobial activity is discussed.

Received: 5 December 2005
Accepted: 31 July 2006

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