Short Communication

Epithelial Irritation Effect of 1-Bromopropane,
an Alternative Solvent to Chlorofluorocarbons

Ágnes Pálovics

Department of Experimental Occupational Hygiene, National Institute of Occupational Health, József Fodor National Center for Public Health, Budapest, Hungary

Corresponding author: Ágnes Pálovics
    Department of Experimental Occupational Hygiene
    National Institute of Occupational Health
    József Fodor National Center for Public Health
    P.O. Box 22
    H-1450 Budapest, Hungary
    Telephone: +361 476 11 00/2565
    Fax number: +361 216 99 07
    E-mail: palovics@fjokk.hu

CEJOEM 2004, Vol.10. No.4.: 333–337


Key words:
1-Bromopropane, acute dermal irritation, rabbit, skin, local effects, HET-CAM


Abstract:
Irritation effect of 1-bromopropane was tested on the chorioallantois membrane of hen’s eggs and on the skin of rabbits. Local application of the substance caused copious haemorrhage and moderate lysis of blood vessels in the chorioallantois membrane of hen’s eggs and reversible damage (erythema, oedema) to the rabbit’s skin. Complete regeneration of the skin took place in 8 days. On the basis of both models 1-bromopropane proved to be irritative to the skin and is likely to be irritative to the eye and the mucous membranes of the respiratory system.


Received: 22 June 2004
Accepted: 5 January 2005

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